North Carolina

Here are the 3 shots NC doctors say to get this fall (+ when to get them)

Key Takeaways
Key Takeaways

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  • Doctors recommend flu, COVID and RSV vaccines before respiratory season peaks.
  • Eligibility and timing vary; high-risk groups advised to consult physicians first.
  • Pharmacies, clinics and retailers offer vaccines, but availability may differ.

As cooler weather sets in, so does the season for respiratory illnesses – and doctors say the best defense is already within reach.

North Carolina health experts are urging people to roll up their sleeves this fall, with three key shots that can help keep serious illness at bay.

But the timing of each dose can make a big difference in how well they work.

Here are the vaccines you need to prepare for the respiratory illness season this year.

Flu vaccine

Who should get it: All children and adults six months and older, unless there is a specific medical reason to avoid it.

When you should get it: In September or October, before flu activity begins to increase.

It takes one to three weeks to develop immunity from a vaccine, so if you’re going to travel for the holidays later this year, there’s still time to get that vaccine and immunity, Dr. David Weber, an infectious disease specialist at UNC Health, previously told The News & Observer.

“It’s like mailing your letter to Santa if you want a Christmas present to arrive,” Weber said. “You can’t wait until Christmas Eve to mail it off. But there’s still time right now.”

A high-dose flu vaccine is available for those aged 65 and older to boost their immune system response to the virus, as they’re generally at high risk for severe flu and complications, according to Mayo Clinic.

A nurse readies a syringe during a vaccination.
A nurse readies a syringe during a vaccination. Matt Stone/The Louisville Courier Journal Matt Stone/The Louisville Courier Journal / USA TODAY NETWORK

RSV vaccine

Who should get it: Adults age 75 and older, adults 60-74 with chronic medical conditions, pregnant people in their second or third trimester, infants younger than eight months who were born shortly before or are entering their first RSV season and infants aged eight to 19 months who are at increased risk for severe RSV disease and entering their second RSV season.

When you should get it: Late summer or early fall

For most healthy people, respiratory syncytial virus (RSV) resembles a common cold and clears within a week, according to UNC Health. But infants, those with weak immune systems and people with chronic lung conditions are at higher risk for severe illness, such as bronchiolitis or pneumonia.

An estimated 110,000-180,000 adults ages 50 and older in the United States are hospitalized due to RSV annually, according to the Centers for Disease Control and Prevention (CDC).

COVID-19 vaccine

Who should get it: Though the official recommendation from the CDC has been lifted, health providers generally recommend the COVID vaccine for anyone aged six months and older.

When you should get it: September or October

North Carolina now allows adults 65 and older, along with those with certain health risks, to get COVID-19 vaccines at pharmacies without a prescription, The Charlotte Observer previously reported. But with new CDC guidance shifting to “shared clinical decision making,” access may vary, and experts urge people to check with their pharmacy before booking an appointment.

Though the official recommendation from the CDC has been lifted, health providers generally recommend the COVID vaccine for anyone aged six months and older.
Though the official recommendation from the CDC has been lifted, health providers generally recommend the COVID vaccine for anyone aged six months and older. Getty Images

Can you get your COVID, flu and RSV shots at the same time?

Yes, Weber previously told the Observer.

But since all three shots aren’t recommended for everyone, it may be best to speak with your doctor first.

Where to get a COVID, flu or RSV vaccine in NC

You can visit the following places for vaccines in North Carolina:

  • Pharmacies: Walk in or schedule appointments at national pharmacies like CVS and Walgreens. You can also inquire with local neighborhood pharmacies.
  • Grocery and big box stores: Walk in or schedule appointments at stores like Walmart, Target, Harris Teeter, Publix and Carlie C’s.
  • Your healthcare provider: Of course, you can contact your doctor for an appointment.

For COVID vaccines, pharmacies may ask you if you are 65 or older or have an underlying health condition, Dr. David Wohl, an infectious disease specialist at UNC Health, previously told the Observer. If you don’t, you could be turned away.

“My advice to people is to call your pharmacy and tell them your situation and see what they say,” Wohl said. “If they say “yes,” great. If not, you’ll probably have to call a clinic.”

Ask the North Carolina Service Journalism Team

Questions about life in North Carolina? Or have a tip or story idea you’d like to share? The service journalism teams at The News & Observer and The Charlotte Observer want to hear from you.

You can submit your question by filling out this form.

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This story was originally published September 26, 2025 at 6:00 AM with the headline "Here are the 3 shots NC doctors say to get this fall (+ when to get them)."

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Evan Moore
The Charlotte Observer
Evan Moore is a service journalism reporter for the Charlotte Observer. He grew up in Denver, North Carolina, where he previously worked as a reporter for the Denver Citizen, and is a UNC Charlotte graduate.
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