The Durham Fire Department answered a call to a structure fire at 706 N. Driver St. at 8:09 p.m. Thursday.
The dwelling was not occupied and had no utilities in service, according to DFD Deputy Chief Chris Iannuzzi.
Iannuzzi said firefighters were greeted the scene by heavy smoke visible from the room of the one-story residential structure.
Firefighters gained control of the fire in 17 minutes, Iannuzzi said, but the blaze caused heavy fire, smoke, and water damage throughout the structure, which included a basement
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Thirty-one firefighters responded to the call and firefighters remained on the scene late Thursday night.
Iannuzzi said the cause of the fire remained under investigation Thursday night.